P-2: Protective Effects of Ethyl Pyruvate on Serum Antioxidant Capacity and Testis Germinalepithelium Morphometryin Cyclophosphamide Treated Mice

Background Cyclophosphamide (CP) is a chemotherapeuticdrug which causes deleterious effects on tissue of testicle and increases free radicals in the body. The aim of this study is to investigate protective effects of ethyl pyruvate (EP) on improvement of testicle inCP treated animals. MaterialsAndMethods In this study, 15 male mice(6-8 weeks) were divided into 3 groups. Control group receivednormal saline (0.1ml/day, IP), CP group received CP (15 mg/kg/week, IP), and CP+EP group treated with EP (40 mg/kg/day,IP) along with CP. After 35 days, serum total antioxidant capacity (TAC)and samples of testis were used for measurement of the germinal epitheliumthickness and malondialdehyde (MDA) assaying. Results This study showed that mean thickness of germinal epithelium in the CP+EP group were higher than those of the CP group (P